ALC-0315

ALC-0315

ALC-0315 is a synthetic amino lipid. It is a colorless oil. ALC-0315 is one of four components that form lipid nanoparticles (LNPs) in mRNA-based COVID-19 vaccines. It encapsulates and protects the fragile mRNA which is the active ingredient in these drugs. IUPAC name: [(4-Hydroxybutyl)azanediyl]di(hexane-6,1-diyl) bis(2-hexyldecanoate). The pKa is 6.09. Reagent grade, for research use only.

Molecular structure of the compound BP-25498
    • Unit
    • Price
    • Qty
    • 50 MG
    • $300.00
    • 100 MG
    • $500.00
    • 250 MG
    • $720.00
    • 1 G
    • $1650.00

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Product Citations

  1. Boldyrev, I.A., Shendrikov, V.P., Vostrova, A.G. et al. A Route to Synthesize Ionizable Lipid ALC-0315, a Key Component of the mRNA Vaccine Lipid Matrix. Russ J Bioorg Chem 49, 412–415 (2023). https://doi.org/10.1134/S1068162023020061
    https://link.springer.com/article/10.1134/S1068162023020061
  2. Kirshina, A., Vasileva, O., Kunyk, D., Seregina, K., Muslimov, A., Ivanov, R., & Reshetnikov, V. (2023). Effects of Combinations of Untranslated-Region Sequences on Translation of mRNA. Biomolecules, 13(11), 1677.
    https://www.mdpi.com/2218-273X/13/11/1677
  3. Li, Zhongyu, Xue-Qing Zhang, William Ho, Xin Bai, Dabbu Kumar Jaijyan, Fengqiao Li, Ranjeet Kumar et al. "Lipid-Polymer Hybrid “Particle-in-Particle” Nanostructure Gene Delivery Platform Explored for Lyophilizable DNA and mRNA COVID-19 Vaccines. Advanced Functional Materials. 2022
    https://onlinelibrary.wiley.com/doi/full/10.1002/adfm.202204462
  4. Reshetnikov, V., Terenin, I., Shepelkova, G., Yeremeev, V., Kolmykov, S., Nagornykh, M., ... & Ivanov, R. (2024). Untranslated Region Sequences and the Efficacy of mRNA Vaccines against Tuberculosis. International Journal of Molecular Sciences, 25(2), 888.
    https://www.mdpi.com/1422-0067/25/2/888