TCO

TCO

TCO reagents, TCO linker is a class of click chemistry labeling reagents containing a very reactive TCO group (trans-cycloctene), TCO reagent is highly reactive with tetrazine in an inverse electron demand Diels Alder (IEDDA) reaction followed by a retro-DA reaction to eliminate nitrogen gas. TCO with PEG will increase the compound’s solubility. TCO reagents have been applied in labeling live cells, molecular imaging and other bioconjugation applications.
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