TCO-PEG

TCO-PEG

TCO PEG linkers (reagents) are a class of PEG linkers with PEG attached to a TCO group (trans-cycloctene), TCO reagent is highly reactive with tetrazine in an inverse electron demand Diels Alder (IEDDA) reaction followed by a retro-Diels Alder reaction to eliminate nitrogen gas. This is a fast reaction with a second order rate constant of 2000 M−1–s−1 (in 9:1 methanol/water) allowing modification of biomolecules at very low concentrations. Reactions have also been performed using TCO or norbornenes as dienophiles at second order rates on the order of 1 M−1•s−1 in aqueous media. This reaction has been applied in labeling live cells, molecular imaging and other bioconjugation applications.
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