Tetrazine-PEG

Tetrazine-PEG

The tetrazine ligation is the reaction of a trans-cyclooctene and an s-tetrazine in an inverse electron demand Diels Alder (IEDDA) reaction followed by a retro-Diels Alder reaction to eliminate nitrogen gas. This is a fast reaction with a second order rate constant of 2000 M−1–s−1 (in 9:1 methanol/water) allowing modification of biomolecules at very low concentrations. This ligation can be performed in aqueous media with very fast speed. Reactions have also been performed using TCO or norbornenes as dienophiles at second order rates on the order of 1 M−1•s−1 in aqueous media. The reaction has been applied in labeling live cells and other bio-entities.
Product Number
Product Name
Structure
M.W.
Purity
Details
Methyltetrazine-amine HCl salt
201.2
95%
 
Methyltetrazine-propylamine HCl salt
245.3
95%
Methyltetrazine-PEG4-amine HCl salt
363.4
95%
Methyltetrazine-PEG12-amine HCl salt
752.3
96%
Methyltetrazine-PEG24-amine HCl salt
1244.5
98%
 
 
Tetrazine-Acid
216.2
95%
 
Methyltetrazine-acid
230.2
95%
Methyltetrazine-PEG4-acid
436.5
95%
Methyltetrazine-PEG8-acid
612.7
95%
Methyltetrazine-PEG12-acid
788.9
98%
Methyltetrazine-PEG24-acid
1317.5
97%
 
 
Tetrazine-NHS ester
313.3
95%
 
Methyltetrazine-NHS ester
327.3
95%
 
Methyltetrazine-Sulfo-NHS ester
429.3
90%
 
Tetrazine-PEG5-NHS ester
604.6
95%
 
Methyltetrazine-PEG5-NHS ester
533.5
95%
Methyltetrazine-PEG8-NHS ester
709.8
98%
Methyltetrazine-PEG12-NHS ester
886.0
98%
Methyltetrazine-PEG24-NHS ester
1414.6
98%
 
 
Methyltetrazine-PEG8-PFP ester
778.7
98%
 
 
4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenol
188.2
98%
 
 
Methyltetrazine-PEG5-alkyne
402.5
95%
 
Methyltetrazine-amido-PEG5-alkyne
487.6
98%
 
 
Methyltetrazine-PEG4-azide
389.4
95%
 
Methyltetrazine-amido-PEG7-azide
606.7
98%
 
 
Biotin-PEG4-methyltetrazine
589.7
95%
 
 
Methyltetrazine-PEG12-DBCO
1003.2
95%
 
Methyltetrazine-DBCO
683.7
95%
 
 
Methyltetrazine-PEG4-maleimide
514.5
95%
 
Methyltetrazine-PEG12-Maleimide
952.1
98%
 
 
Methyltetrazine-PEG4-NH-Boc
463.5
98%
Methyltetrazine-PEG24-NH-Boc
1344.6
98%
 
 
Methyltetrazine-PEG4-t-butyl ester
492.6
98%
Methyltetrazine-PEG12-t-butyl ester
845.0
98%
Methyltetrazine-PEG24-t-butyl ester
1373.6
98%
 
 
Methyltetrazine-PEG5-triethoxysilane
639.8
98%
 
 
Gly-Gly-Gly-PEG4-methyltetrazine
534.6
98%
 
 
TAMRA-PEG4-Tetrazine
846.9
90%
 
TAMRA-PEG4-Methyltetrazine
775.9
90%