Peptide Linkers

Peptide Linkers

Peptide Linkers are developed as the critical component of ADC linkers which play vital roles in the overall success of the ADC. By introducing a PEG into the linker, it increases the water-solubility and helping finetune the drug DMPK. A well-designed linker helps the antibody to selectively deliver a cytotoxic drug to tumor cells and accurately releases the drug at tumor site. Two kinds of ADC linkers are used in current ADC drugs: cleavable linkers and non-cleavable linkers.

Featured products: PEG-Val-Cit, PEG-Val-Cit-PAB, Val-Cit-PAB-PNP, DBCO, BCN, Azide, Tetrazine, TCO, MMAE, DM1, DM4 and other payloads.

BroadPharm also offers customer-oriented ADC linker synthesis and services to our customers worldwide.

Product Number
Product Name
Structure
M.W.
Purity
Details
Val-Cit
274.3
98%
 
Val-Cit-PAB-OH
379.5
95%
 
Fmoc-Val-Cit-PAB-OH
601.7
95%
 
Fmoc-Val-Cit-PAB-PNP
766.8
95%
 
Boc-Val-Cit
374.4
95%
 
Boc-Val-Cit-PAB
479.6
95%
 
Boc-Val-Cit-PAB-PNB
644.7
95%
 
MC (C5)-Val-Cit
452.5
98%
 
MC-Val-Cit-PAB-OH
572.7
96%
 
MC-Val-Cit-PAB-PNP
737.8
95%
 
SPDP-Val-Cit-PAB-OH
576.7
98%
 
SPDP-Val-Cit-PAB-PNP
741.8
98%
 
Mal-PEG2-Val-Cit-PAB-OH
618.7
95%
Mal-PEG4-Val-Cit-PAB-OH
706.8
96%
 
Mal-PEG1-Val-Cit-PAB-PNP
739.7
96%
Mal-PEG4-Val-Cit-PAB-PNP
871.9
97%
 
Mal-amido-PEG2-Val-Cit-PAB-OH
689.8
98%
 
Mal-amido-PEG2-Val-Cit-PAB-PNP
854.9
98%
 
Azido-PEG1-Val-Cit-PAB-OH
520.6
96%
Azido-PEG3-Val-Cit-PAB-OH
608.7
96%
Azido-PEG4-Val-Cit-PAB-OH
652.8
96%
 
Azido-PEG3-Val-Cit-PAB-PNP
773.8
95%
 
BCN-PEG3-Val-Cit
653.8
98%
 
BCN-PEG3-VC-PFP Ester
819.8
96%
 
DBCO-PEG4-Val-Cit-PAB-PNP
1079.2
98%
 
TCO-PEG4-Val-Cit-PAB-PNP
944.1
98%
 
 
Boc-Val-Gly-OH
274.3
98%
 
Mal-amido-PEG8-Val-Gly
748.8
98%
 
Mal-amido-PEG8-val-gly-PAB-OH
854.0
98%
 
 
Boc-Gly-Gly
232.2
95%
 
Boc-Gly-Gly-Gly-OH
289.3
97%
 
Fmoc-Gly-Gly-Gly-OH
411.4
95%
 
Gly-Gly-Gly-PEG4-methyltetrazine
534.6
98%
 
Gly-Gly-Gly-PEG3-TCO
515.6
95%
 
Gly-Gly-Gly-PEG4-DBCO
694.8
98%
 
TCO-PEG4-Fmoc-Gly-Gly-Gly
781.9
95%
 
 
Fmoc-PEG4-Ala-Ala-Asn-PAB
849.0
95%
 
Azido-PEG5-Ala-Ala-Asn-PAB
696.8
95%
 
Fmoc-PEG3-Ala-Ala-Asn(Trt)-PAB
1047.2
96%
 
Azido-PEG4-Ala-Ala-Asn(Trt)-PAB
895.0
96%
 
Fmoc-PEG3-Ala-Ala-Asn(Trt)-PAB-PNP
1212.3
95%
 
 
Auristatin E
732.0
95%
Val-Cit-PAB-MMAE
1123.5
95%
MC-Val-Cit-PAB-MMAE
1316.7
98%
Fmoc-Val-Cit-PAB-MMAE
1345.7
98%
 
Amino-PEG4-Val-Cit-PAB-MMAE
1370.7
98%
 
Azido-PEG4-Val-Cit-PAB-MMAE
1396.7
98%
 
endo-BCN-PEG4-Val-Cit-PAB-MMAE
1547.0
98%
 
Mal-PEG8-Val-Cit-PAB-MMAE
1627.0
 
MC-MMAF
925.2
98%
MMAF-methyl ester
746.0
 
Monomethyl Dolastatin 10
771.1
95%
 
Maytansinoid
565.1
98%
Maytansinoid AP-3
635.2
95%
 
DM1-MCC-PEG3-biotin
1376.1
95%
 
 
Cabazitaxel
836.0
95%
DeBoc-Cabazitaxel
735.8
98%
 
Paclitaxel
853.9
95%
2'-O-TBDMS-Paclitaxel
968.2
98%
7-O-(Amino-PEG4)- paclitaxel
1101.2
98%
7-O-(Cbz-N-amido-PEG4)- paclitaxel
1235.4
98%
 
Doxorubicin HCl
543.5
96%
N-(Iodoacetamido)-Doxorubicin
711.5
N-(4-((2,5-dioxo-2H-pyrrol-1(5H)-yl)methyl)cyclohexane)-Doxorubicin
762.8
98%
MC-Val-Cit-Doxorubicin
1142.2
98%
 
7-Ethyl-10-hydroxycamptothecin
392.4
98%
 
Gambogic acid
628.8