TCO-PEG

TCO-PEG

The tetrazine ligation is the reaction of a trans-cyclooctene and an s-tetrazine in an inverse electron demand Diels Alder (IEDDA) reaction followed by a retro-Diels Alder reaction to eliminate nitrogen gas. This is a fast reaction with a second order rate constant of 2000 M−1–s−1 (in 9:1 methanol/water) allowing modification of biomolecules at very low concentrations. This ligation can be performed in aqueous media with very fast speed. Reactions have also been performed using TCO or norbornenes as dienophiles at second order rates on the order of 1 M−1•s−1 in aqueous media. The reaction has been applied in labeling live cells and other bio-entities.
Product Number
Product Name
Structure
M.W.
Purity
Details
TCO-PEG3-acid
373.5
95%
TCO-PEG4-acid
417.5
95%
TCO-PEG6-acid
505.6
95%
TCO-PEG8-acid
593.7
95%
TCO-PEG12-acid
769.9
95%
TCO-PEG24-acid
1298.6
95%
TCO-PEG36-acid
1827.2
95%
 
 
TCO-NHS ester
267.3
95%
TCO-PEG3-NHS ester
470.5
95%
TCO-PEG4-NHS ester
514.6
95%
TCO-PEG6-NHS ester
602.7
95%
TCO-PEG8-NHS ester
690.8
95%
Fmoc-N-amido-PEG16-acid
1016.2
98%
TCO-PEG12-NHS ester
867.0
95%
TCO-PEG24-NHS ester
1395.6
95%
TCO-PEG36-NHS ester
1924.3
95%
 
TCO-PEG2-Sulfo-NHS ester
679.8
95%
 
 
TCO-PEG8-TFP ester
741.8
95%
TCO-PEG12-TFP ester
918.0
95%
 
 
TCO-PNB Ester
291.3
95%
 
 
TCO-amine hydrochloride
226.3
95%
TCO-PEG2-amine
300.4
95%
TCO-PEG3-amine
344.5
95%
TCO-PEG4-amine
388.5
95%
TCO-PEG6-amine
476.6
95%
TCO-PEG8-amine
564.7
95%
 
TCO-C3-PEG3-C3-amine
372.5
95%
 
 
TCO-PEG4-biotin
614.8
95%
 
 
TCO-PEG4-DBCO
675.8
95%
TCO-PEG12-DBCO
1028.3
95%
 
 
TCO-PEG9-maleimide
759.9
95%
 
 
TCO-PEG3-triethoxysilane
576.8
95%
 
 
TCO-OH
126.2
95%
TCO-PEG3-alcohol
301.4
95%
 
 
TCO-PEG2-TCO
452.6
95%
TCO-PEG3-TCO
496.6
95%
TCO-PEG4-TCO
540.7
95%
TCO-PEG8-TCO
716.9
95%
TCO-PEG-TCO, MW5K
 
 
Gly-Gly-Gly-PEG3-TCO
515.6
95%
 
TCO-PEG4-Fmoc-Gly-Gly-Gly
781.9
95%