COOH-PLGA(10k)-PEG(5k)-MAL has two distinct block of polymers, i.e. hydrophobic poly(lactide-co-glycolide) (PLGA) and hydrophilic PEG blocks. In water, the polymer self-assembles with the PLGA being shielded from water by the PEG. The PLGA core can be used to encapsulate hydrophobic drugs while the PEG shell not only provides protection against degradation but also enables a stealth behavior which is a prerequisite for successful in vivo translation of nanomedicine to achieve long blood circulation and targeted delivery. The terminal carboxyl can react with amine in the presence of activator, such as HATU or EDC, to form a stable amide linkage. The maleimide moiety can react with thiol (SH) at pH 6.5-7.5 via formation of thioether linkage. Reagent grade, for research purpose.
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