Customer Service

Custom Synthesis

At BroadPharm, we specialize in providing high-quality, timely custom synthesis and contract services to clients worldwide. Leveraging our deep technical expertise and years of experience, we deliver cost-effective solutions tailored to your research and development needs.

Custom Synthesis Capabilities

We offer custom synthesis across a wide range of compound types, including but not limited to:

PEG Linkers, Click Chemistry Linkers, and Bioconjugation Linkers

• Linear and branched linkers
• Hydrophilic and hydrophobic linkers
• PEG-lipid linkers and hybrid linkers
• Click chemistry crosslinkers
• Fluorescent-tagged linkers
• Biotin-conjugated linkers
• Custom lengths and functional groups, including:
• Azide, DBCO, TCO, tetrazine, active esters, and more

Available in:

• Research to bulk quantities (>kg)
• Research-grade to GMP-grade
• Fast turnaround and global delivery

ADC Linkers & Payloads

We provide a full spectrum of Antibody-Drug Conjugate (ADC) synthesis services:

• Cleavable and non-cleavable ADC linkers
• Peptide-based linkers
• Custom ADC payload synthesis
• Linker-payload conjugates
• End-to-end services: from synthesis to full antibody-payload conjugation

Available in:

• Research to bulk quantities (>kg)
• Research-grade to GMP-grade
• Rapid and reliable delivery

Custom Lipid Synthesis

We synthesize a wide variety of lipid molecules tailored to your specifications:

• Ionizable lipids, cationic lipids, PEGylated lipids, helper lipids, and branched lipids
• PEG- or sugar-conjugated lipids

Available in:

• Research to bulk quantities (>kg)
• Research-grade to GMP-grade
• Rapid and reliable delivery

Nucleotide & Phosphoramidite Synthesis

• Custom synthesis of nucleotides and phosphoramidites for oligonucleotide and RNA-related research
• Rapid and reliable delivery

Custom Peptide Synthesis

• High-purity peptides synthesized to your sequence and specifications
• Available in various scales and purities, including modifications and labeling

Available in:

• Research to bulk quantities (>kg)
• Research-grade to GMP-grade
• Rapid and reliable delivery

Custom Conjugation Service

As a global leader in advanced PEG and ADC linker technologies, BroadPharm offers extensive expertise in a wide range of protein labeling and conjugation techniques. We provide flexible solutions tailored to your R&D needs, including conjugation using client- supplied antibodies or proteins.

Our most commonly requested custom conjugation services include:

• Antibody-Drug Conjugation (ADC) and Drug-to-Antibody Ratio (DAR) Analysis
• Protein and Peptide Conjugation
• Enzyme Conjugation
• Oligonucleotide Conjugation
• Biotinylation
• Fluorescent Labeling with a broad selection of dyes (e.g., BP Fluor488, Fluor647, 800CW) and fluorescent proteins (e.g., APC, PerCP, R-PE)

For small-scale conjugation needs (≤ 1 mg), we also offer a range of Antibody Conjugation Kits for your convenience.

To inquire or request a quote, please contact us at:
sales@broadpharm.com
858-677-6760

Deliverables and Analytical Documentation

Each project includes comprehensive documentation, which may contain:

• Final conjugated product
• Purity profile
• High-performance liquid chromatography (HPLC) data (including eluent ratio, separation time, and column specifications)
• Mass spectrometry (MS) data

All custom conjugation products are manufactured under stringent quality control standards to ensure performance, consistency, and customer satisfaction.

Project Workflow

Frequently Asked Questions

1. What is the typical turnaround time for custom antibody conjugation? Project timelines vary based on material availability and project scope. Most orders are completed within 1-2 weeks after receiving all required materials. Please contact us for a precise timeline.
2. Is there a minimum order requirement? Yes. For antibody-oligonucleotide conjugation, the minimum quantity is 100 µg. For all other services, the minimum is 1 mg.
3. What validation methods does BroadPharm use? Our QC process includes reliable analytical techniques such as HIC-HPLC, SEC, SDS-PAGE, and endotoxin testing to ensure high product quality.
4. Can clients provide their own antibodies for conjugation? Yes, we accept customer-supplied antibodies for custom conjugation projects.
5. Can large-volume orders be delivered in a single vial? Yes. We offer flexible packaging options, including single large vials or multiple smaller vials, based on your preference.

Reagent Inquiry Form

Complete the form with your requirements; a conjugation expert will contact you to get your project started.