3,4-Dibromo-Mal-amido-PEG4-azide is a PEG linker featuring a dibromomaleimide and an azide. The unsaturated dibromo motif is a covalent ligand for thiol groups, and may be used to label cysteine residues in proteins. The presence of two leaving groups on this molecule allows this linker to bind two thiols at a time. Meanwhile, the azide is a click chemistry handle that can readily react with terminal alkynes and strained cyclooctynes like BCN or DBCO.
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