TCO-PEG4-Val-Cit-PFP Ester is a cleavable ADC linker featuring a TCO group, a Val-Cit dipeptide, and a PFP ester. The TCO group is reactive towards tetrazine groups on target compounds in a high yielding click reaction. PFP is a good leaving group which is readily displaced by amines to form amides. Finally the Val-Cit dipeptide is easily cleaved by enzymes to allow for payload release within the cell.
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