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DBCO-PEG4-Desthiobiotin

DBCO-PEG4-Desthiobiotin is a single-ring, sulfur-free analog of biotin that binds to streptavidin with nearly equal specificity but less affinity than biotin (Kdハ= 1011ハvs. 1015M, respectively). Consequently, desthiobiotinylated proteins can be eluted readily and specifically from streptavidin affinity resin using mild conditions based on competitive displacement with free biotin. For pull-down experiments with biological samples, this soft-release characteristic of desthiobiotin also helps to minimize co-purification of endogenous biotinylated molecules, which remain bound to streptavidin upon elution of the target protein complexes with free biotin. DBCO is commonly used for copper-free Click Chemistry reactions.

Catalog #:
BP-22451
Name:
DBCO-PEG4-Desthiobiotin
Formula:
C39H53N5O8
MW:
719.9
CAS:
2032788-37-5
Purity:
95%
Availability:
In Stock
Ships within:
24 hours
Storage condition:
-20 ° C
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