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Desthiobiotin-PEG3-NHS ester

Desthiobiotin is a single-ring, sulfur-free analog of biotin that binds to streptavidin with nearly equal specificity but less affinity than biotin (Kd = 1011 vs. 1015 M, respectively). Consequently, desthiobiotinylated proteins can be eluted readily and specifically from streptavidin affinity resin using mild conditions based on competitive displacement with free biotin. For pull-down experiments with biological samples, this soft-release characteristic of desthiobiotin also helps to minimize co-purification of endogenous biotinylated molecules, which remain bound to streptavidin upon elution of the target protein complexes with free biotin.

Catalog #:
BP-24457
Name:
Desthiobiotin-PEG3-NHS ester
Formula:
C23H38N4O9
MW:
514.6
CAS:
2411681-92-8
Purity:
98%
Availability:
In Stock
Ships within:
24 hours
Storage condition:
-20 ° C
Shipping:
Ambient Temperature
Solubility:
Water, DMSO, DCM, DMF
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