PEI-g(25k)-PEG(2k), 10% PEG ratio is a graft copolymer of branched PEI (bPEI), which is modified with a 10% ratio of 1,000 MW PEG. Branched PEI shows a variable solubility in water and can have a wide amount of uses in industry. The hydrophilic PEG spacer increases solubility in aqueous media. Copolymers of cationic poly(ethyleneimine) grafted with polyethylene glycol (PEG) (PEI-g-PEG) can improve the in vitro and in vivo delivery of antisense oligonucleotides (ASOs) to cells and tissues. PEG-PEI-ASO nanoparticulates can be prepared with a dynamic range of size, surface charge, and stability by varying the MW of PEI, as well as the nature of PEG shielding. PEG-PEI copolymers are readily functionalized for enhanced efficacy and specificity of cellular and tissue targeting.
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