PEI-g(10k)-PEG(5k)-Thiol, 20% PEG ratio is a graft copolymer of branched PEI (bPEI), which is modified with a 20% ratio of 1,000 MW PEG. Branched PEI shows a variable solubility in water and can have a wide amount of uses in industry. The hydrophilic PEG spacer increases solubility in aqueous media. The thiol group reacts with maleimide, OPSS, vinylsulfone and transition metal surfaces including gold, silver, etc. Copolymers of cationic poly(ethyleneimine) grafted with polyethylene glycol (PEG) (PEI-g-PEG) can improve the in vitro and in vivo delivery of antisense oligonucleotides (ASOs) to cells and tissues. PEG-PEI-ASO nanoparticulates can be prepared with a dynamic range of size, surface charge, and stability by varying the MW of PEI, as well as the nature of PEG shielding. PEG-PEI copolymers are readily functionalized for enhanced efficacy and specificity of cellular and tissue targeting.
Usually ships within 24 hours.