BCN-PEG3-VC-PFP Ester is a cleavable ADC linker. PFP ester can be reactive with amine-bearing molecule to form stable amide bond. The Val-Cit will specifically be cleaved by Cathepsin B. As this enzyme is only present in the lysosome, the ADC payload will be released only in the cell. The BCN group can react with azide-tagged biomolecules.
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