DBCO-PEG4-NHS ester

DBCO-PEG4-NHS ester

DBCO-PEG4-NHS Ester is a click chemistry PEG reagent containing NHS ester that is able to react specifically and efficiently with primary amines (e.g. the side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic condition to form a covalent bond. The hydrophilic PEG spacer arm improves water solubility and provides a long and flexible connection that minimizes steric hindrance involved with ligation. DBCO is commonly used for copper-free Click Chemistry reactions. Please contact us for GMP-grade inquiries.

Molecular structure of the compound BP-22288
    • Unit
    • Price
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    • 50 MG
    • $210.00
    • 100 MG
    • $340.00
    • 250 MG
    • $600.00
    • 500 MG
    • $980.00

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Product Citations

  1. Bian, Y. (2025). Precision Adjuvant Design Enabling Tailored Nanoparticle Immunization Platforms for Oxycodone and Other Substance Abuse Vaccines.
    https://vtechworks.lib.vt.edu/items/14ef956b-0f57-463d-a685-bb9a4877b076
  2. Dong, Y., You, F., Zhang, Y., Sun, H., Cheng, R., Zhao, S., ... & Zhong, Z. (2024). CD7 Nanobody-Based Immuno-Nanotoxin for Targeted Treatment of T-Cell Acute Lymphoblastic Leukemia. ACS Applied Nano Materials, 7(7), 7195-7202.
    https://doi.org/10.1021/acsanm.3c06253
  3. Krishnan, M. A., Alimi, O. A., Pan, T., Kuss, M., Korade, Z., Hu, G., ... & Duan, B. (2024). Engineering Neurotoxin-Functionalized Exosomes for Targeted Delivery to the Peripheral Nervous System. Pharmaceutics, 16(1), 102.
    https://www.mdpi.com/1999-4923/16/1/102
  4. Li, Y., Awasthi, S., Liu, P., Protopopova, A., & Mayer, M. (2025). Selective and Controllable Trapping of Single Proteins in Nanopores using Reversible Covalent Bonds. bioRxiv, 2025-09.
    https://www.biorxiv.org/content/10.1101/2025.09.11.675362v1.full
  5. Marzolini, N., Brysgel, T. V., Essien, E. O., Rahman, R. J., Wu, J., Majumder, A., ... & Brenner, J. S. (2025). Targeting DNA-LNPs to Endothelial Cells Improves Expression Magnitude, Duration, and Specificity. bioRxiv, 2025-07.
    https://www.biorxiv.org/content/10.1101/2025.07.09.663747v1.full
  6. Mauser, Ava, Daniel F. Quevedo, Boya Zhang, Yazmin Hernandez, Anthony Berardi, William Brown, Sophia Lee Enzyme?based Synthetic Protein Nanoparticles as Colloidal Antioxidants. Advanced Therapeutics. 2023
    https://onlinelibrary.wiley.com/doi/full/10.1002/adtp.202300007
  7. Santiago, J. I., Ahmed, I., Hahn, J., Rubino, A., Dubnau, D., Neiditch, M. B., & Mickolajczyk, K. J. (2025). Reversible DNA condensation drives natural transformation. bioRxiv, 2025-07.
    https://www.biorxiv.org/content/10.1101/2025.07.24.666597v1.full
  8. Studer, Tetiana, Daria Morina, Inga S. Shchelik, and Karl Gademann.  Biohybrid Microswimmers for Antibiotic Drug Delivery Based on a Thiol?Sensitive Release Platform. Chemistry-A European Journal. 2023
    https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/chem.202203913
  9. Zhao, Z., Ledezma, D. K., Affonso de Oliveira, J. F., Omole, A. O., & Steinmetz, N. F. (2025). A cowpea mosaic virus adjuvant conjugated to liposomes loaded with tumor cell lysates as an ovarian cancer vaccine. Nature Communications, 16(1), 5047.
    https://www.nature.com/articles/s41467-025-60239-w