DMG-PEG 2000

DMG-PEG 2000

DMG-PEG 2000, also called 1,2-dimyristoyl-rac-glycero-3-methoxypolyethylene glycol-2000, is used for liposome preparation. DMG-PEG 2000 has become known for lipid nanoparticle (LNP) preparation for siRNA (small interfering RNA) delivery in the COVID-19 vaccine development.

Molecular structure of the compound BP-25496
    • Unit
    • Price
    • Qty
    • 500 MG
    • $210.00
    • 1 G
    • $350.00
    • 2 G
    • $650.00
    • 5 G
    • $1000.00

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Product Citations

  1. Gaisin, K. S., Ryabukhina, E. V., Koroev, D. O., Mikhalyov, I. I., Zhuravlev, E. S., Stepanov, G. A., ... & Vodovozova, E. L. (2025). An Ionizable Cationic Lipid for Intracellular RNA Delivery. Russian Journal of Bioorganic Chemistry, 51(5), 1982-1989.
    https://link.springer.com/article/10.1134/S1068162025602149
  2. Grigoriev, V., Korzun, T., Moses, A. S., Jozic, A., Zhu, X., Kim, J., ... & Taratula, O. (2024). Targeting Metastasis in Head and Neck Squamous Cell Carcinoma Using Follistatin mRNA Lipid Nanoparticles. ACS nano, 18(49), 33330-33347.
    https://pubs.acs.org/doi/full/10.1021/acsnano.4c06930
  3. Hossainy, S., Kang, S., Gómez Medellín, J. E., Alpar, A. T., Refvik, K. C., Ma, Y. Y., ... & Hubbell, J. A. (2025). Thermoreversibly assembled polymersomes for highly efficient loading, processing and delivery of protein and siRNA biologics. Nature Biomedical Engineering, 1-18.
    https://www.nature.com/articles/s41551-025-01469-7
  4. Kukushkin, I., Vasileva, O., Kunyk, D., Kolmykov, S., Sokolova, T., Muslimov, A., ... & Reshetnikov, V. (2024). Effects of Various Poly (A) Tails on Luciferase Expression. Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry, 18(3), 263-274.
    https://link.springer.com/article/10.1134/S1990750824600055
  5. Li, Y., Ambati, S., Meagher, R. B., & Lin, X. (2025). Developing mRNA lipid nanoparticle vaccine effective for cryptococcosis in a murine model. npj Vaccines, 10(1), 24.
    https://www.nature.com/articles/s41541-025-01079-z
  6. Reshetnikov, V., Terenin, I., Shepelkova, G., Yeremeev, V., Kolmykov, S., Nagornykh, M., ... & Ivanov, R. (2024). Untranslated Region Sequences and the Efficacy of mRNA Vaccines against Tuberculosis. International Journal of Molecular Sciences, 25(2), 888.
    https://www.mdpi.com/1422-0067/25/2/888
  7. Rubtsova, M., Mokrushina, Y., Andreev, D., Poteshnova, M., Shepelev, N., Koryagina, M., ... & Rubtsov, Y. (2025). A Luciferase-Based Approach for Functional Screening of 5′ and 3′ Untranslated Regions of the mRNA Component for mRNA Vaccines. Vaccines, 13(5), 530.
    https://www.mdpi.com/2076-393X/13/5/530
  8. Schober, G. B., Story, S., & Arya, D. P. (2024). A careful look at lipid nanoparticle characterization: analysis of benchmark formulations for encapsulation of RNA cargo size gradient. Scientific Reports, 14(1), 2403.
    https://www.nature.com/articles/s41598-024-52685-1