Gambogic acid

Gambogic acid

Gambogic acid is a natural product isolated from the resin of Garcinia hurburyi tree, Gambogic acid is a potent apoptosis inducer. It binds covalently to the regulatory subunit B (SPTSSB) of the serine palmitoyltransferase complex and inhibits de novo sphingolipid biosynthesis. Gambogic acid activates caspases in T47D breast cancer cells and inhibits binding of anti-apoptotic proteins to a BH3 peptide. Reagent grade, for research purpose.

Molecular structure of the compound BP-22199
    • Unit
    • Price
    • Qty
    • 100 MG
    • $125.00
    • 500 MG
    • $320.00
    • 1 G
    • $560.00
    • 5 G
    • $2200.00

Usually ships within 24 hours.

Would you like to inquire about custom quantity?
Inquire

Product Citations

  1. Kwan HY, Xu Q, et al Targeted Chinese Medicine Delivery by A New Family of Biodegradable Pseudo-Protein Nanoparticles for Treating Triple-Negative Breast Cancer: In Vitro and In Vivo study. Frontiers in Oncology. 2021. 10
    https://www.frontiersin.org/articles/10.3389/fonc.2020.600298/full
  2. R. Ganugula, M. Arora, S. Dwivedi, D. S. Chandrashekar, S. Varambally, E. M. Scott, and M. N. V. Ravi Kumar.Systemic Anti-Inflammatory Therapy Aided by Curcumin-Laden Double-Headed Nanoparticles Combined with Injectable Long-Acting Insulin in a Rodent Model of Diabetes Eye Disease. ACS Nano. 2023 17 (7), 6857-6874. DOI: 10.1021/acsnano.3c00535
    https://pubs.acs.org/doi/full/10.1021/acsnano.3c00535
  3. Xu Q, Chu CC Development of ROS-responsive amino acid-based poly(ester amide) nanoparticle for anticancer drug delivery. Journal of Biomedical Materials Research. 2020. 109(4). pp. 524-537
    https://onlinelibrary.wiley.com/doi/abs/10.1002/jbm.a.37035