PFI 4
PFI 4 is an SGC chemical probe for the bromodomains of the BRPF (BRomodomain and PHD Finger containing) scaffolding protein BRPF1B. PFI 4 specifically binds to BRPF1B with an IC50 = 172 nM and Kd =13 nM as determined by ITC. PFI 4 reduces recovery time in triple BRD cell construct in FRAP and is potent in cells with IC50 250nM, while showing no effect on BRPF1A. PFI 4 exhibits >100-fold selectivity for BRPF1 over a panel of other bromodomains including BRPF2 (BRD1), BRPF3 and BRD4. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
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Catalog:
BP-25373
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Name:
PFI 4
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Formula:
C21H24N4O3
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MW:
380.5
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CAS:
900305-37-5
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Purity:
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Ships Within:
24 Hours
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Storage Condition:
-20°C
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Shipping:
Ambient Temperature
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Availability:
In Stock
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Datasheet:
View
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SDS:
Inquire about MSDS