XMD 8-92

XMD 8-92


XMD 8-92 is shown to be an extremely selective ERK5 (BMK 1) inhibitor that presents selectivity over 402 diverse kinases. XMD 8-92 shows Kd values of 80 and 190 nM for ERK5 (BMK1) and BRD4 inhibition, respectively. XMD 8-92 also inhibits DCAMKL2, PLK4 and TNK1 (Kd values are 190, 600 and 890 nM). XMD 8-92 has been shown to block growth factor-induced activation of cellular BMK1 and reduces BMK1 activity in in vitro kinase assays. XMD 8-92 reduces BMK1-dependent transactivating activity of MEF2C. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Molecular structure of the compound BP-25377
    • Unit
    • Price
    • Qty
    • 10 MG
    • $120.00
    • 25 MG
    • $260.00
    • 50 MG
    • $450.00

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