ALC-0315

ALC-0315

ALC-0315 is a synthetic amino lipid. It is a colorless oil. ALC-0315 is one of four components that form lipid nanoparticles (LNPs) in mRNA-based COVID-19 vaccines. It encapsulates and protects the fragile mRNA which is the active ingredient in these drugs. IUPAC name: [(4-Hydroxybutyl)azanediyl]di(hexane-6,1-diyl) bis(2-hexyldecanoate). The pKa is 6.09. Reagent grade, for research purpose.

Molecular structure of the compound BP-25498
    • Unit
    • Price
    • Qty
    • 50 MG
    • $285.00
    • 100 MG
    • $350.00
    • 250 MG
    • $700.00
    • 1 G
    • $1600.00

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Product Citations

  1. Binici, B., Rattray, Z., & Perrie, Y. (2025). A comparative study of cationic lipid-enriched LNPs for mRNA vaccine delivery. International Journal of Pharmaceutics, 125941.
    https://www.sciencedirect.com/science/article/pii/S0378517325007781
  2. Boldyrev, I.A., Shendrikov, V.P., Vostrova, A.G. et al. A Route to Synthesize Ionizable Lipid ALC-0315, a Key Component of the mRNA Vaccine Lipid Matrix. Russ J Bioorg Chem 49, 412–415 (2023). https://doi.org/10.1134/S1068162023020061
    https://link.springer.com/article/10.1134/S1068162023020061
  3. Borah, A., Giacobbo, V., Binici, B., Baillie, R., & Perrie, Y. (2025). From in vitro to in Vivo: The Dominant role of PEG-Lipids in LNP performance. European Journal of Pharmaceutics and Biopharmaceutics, 114726.
    https://doi.org/10.1016/j.ejpb.2025.114726
  4. Borah, A., Giacobbo, V., Binici, B., Baillie, R., & Perrie, Y. (2025). From in vitro to in vivo: The Dominant role of PEG-Lipids in LNP performance. European Journal of Pharmaceutics and Biopharmaceutics, 114726.
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    https://academic.oup.com/jpp/article/76/12/1572/7816331
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    https://doi.org/10.21203/rs.3.rs-5461735/v1
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    https://www.sciencedirect.com/science/article/pii/S0378517324013437
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    https://www.mdpi.com/2218-273X/13/11/1677
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  29. Shi, P., Liu, H., Refaat, A., Nguyen, H., Nguyen, A., Miao, K., ... & Wang, X. (2025). Innovative γ-Oryzanol and KC2 Based Lipid Nanoparticles: OryKL Platform Provides Safe and Efficient In Vivo mRNA Delivery.
    https://chemrxiv.org/engage/chemrxiv/article-details/68bfb8ed728bf9025e262993
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