ALC-0315

ALC-0315

ALC-0315 is a synthetic amino lipid. It is a colorless oil. ALC-0315 is one of four components that form lipid nanoparticles (LNPs) in mRNA-based COVID-19 vaccines. It encapsulates and protects the fragile mRNA which is the active ingredient in these drugs. IUPAC name: [(4-Hydroxybutyl)azanediyl]di(hexane-6,1-diyl) bis(2-hexyldecanoate). The pKa is 6.09. Reagent grade, for research use only.

Molecular structure of the compound BP-25498
    • Unit
    • Price
    • Qty
    • 50 MG
    • $285.00
    • 100 MG
    • $350.00
    • 250 MG
    • $700.00
    • 1 G
    • $1650.00

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Product Citations

  1. Boldyrev, I.A., Shendrikov, V.P., Vostrova, A.G. et al. A Route to Synthesize Ionizable Lipid ALC-0315, a Key Component of the mRNA Vaccine Lipid Matrix. Russ J Bioorg Chem 49, 412–415 (2023). https://doi.org/10.1134/S1068162023020061
    https://link.springer.com/article/10.1134/S1068162023020061
  2. De Peña, A. C., Zimmer, D., Gutterman-Johns, E., Chen, N. M., Tripathi, A., & Bailey-Hytholt, C. M. (2024). Electrophoretic Microfluidic Characterization of mRNA-and pDNA-Loaded Lipid Nanoparticles. ACS Applied Materials & Interfaces.
    https://pubs.acs.org/doi/abs/10.1021/acsami.4c00208
  3. Janssens, S., Bosteels, V., Marechal, S., Cloots, E., Van Heddegem, L., Tavernier, S., ... & Le Goff, W. (2024). The unfolded protein sensor IRE1a is essential for homeostatic dendritic cell maturation.
    https://www.researchsquare.com/article/rs-4763670/v1
  4. Kirshina, A., Vasileva, O., Kunyk, D., Seregina, K., Muslimov, A., Ivanov, R., & Reshetnikov, V. (2023). Effects of Combinations of Untranslated-Region Sequences on Translation of mRNA. Biomolecules, 13(11), 1677.
    https://www.mdpi.com/2218-273X/13/11/1677
  5. Li, Zhongyu, Xue?Qing Zhang, William Ho, Xin Bai, Dabbu Kumar Jaijyan, Fengqiao Li, Ranjeet Kumar et al. "Lipid?Polymer Hybrid “Particle?in?Particle” Nanostructure Gene Delivery Platform Explored for Lyophilizable DNA and mRNA COVID?19 Vaccines. Advanced Functional Materials. 2022
    https://onlinelibrary.wiley.com/doi/full/10.1002/adfm.202204462
  6. McMillan, C., Druschitz, A., Rumbelow, S., Borah, A., Binici, B., Rattray, Z., & Perrie, Y. (2024). Tailoring lipid nanoparticle dimensions through manufacturing processes. RSC pharmaceutics.
    https://pubs.rsc.org/en/content/articlehtml/2024/pm/d4pm00128a
  7. Reshetnikov, V., Terenin, I., Shepelkova, G., Yeremeev, V., Kolmykov, S., Nagornykh, M., ... & Ivanov, R. (2024). Untranslated Region Sequences and the Efficacy of mRNA Vaccines against Tuberculosis. International Journal of Molecular Sciences, 25(2), 888.
    https://www.mdpi.com/1422-0067/25/2/888
  8. Shepelkova, G. S., Reshetnikov, V. V., Avdienko, V. G., Sheverev, D. V., Yeremeev, V. V., & Ivanov, R. A. IMPACT OF UNTRANSLATED mRNA SEQUENCES ON IMMUNOGENICITY OF mRNA VACCINES AGAINST M. TUBERCULOSIS IN MICE.
    https://www.researchgate.net/profile/V-Yeremeev/publication/377479822_Impact_of_untranslated_mRNA_sequences_on_immunogenicity_of_mRNA_vaccines_against_M_tuberculosis_in_mice/links/65c1cae634bbff5ba7ef9969/Impact-of-untranslated-mRNA-sequences-on-immunogenicity-of-mRNA-vaccines-against-M-tuberculosis-in-mice.pdf