Bis-sulfone-PEG4-TCO

Bis-sulfone-PEG4-TCO


Bis-sulfone-PEG4-TCO is a bis-alkylating labeling reagent that is selective for the cysteine sulfur atoms from a native disulfide. These reagents undergo bis-alkylation to conjugate both thiols derived from the two cysteine residues of a reduced native disulfide bond such as the interchain disulfide bonds of an antibody. The reaction results in covalent rebridging of the disulfide bond via a three carbon bridge leaving the protein structurally intact. TCO enables fast click chemistry with tetrazine under mild conditions. The hydrophilic PEG spacer increases solubility in aqueous media. The half-life of TCO is short as it will naturally isomerize into CCO (cis-cycloctene) and lose the reactivity. TCO compound is not recommended for long term storage.

Molecular structure of the compound BP-28211
    • Unit
    • Price
    • Qty
    • 50 MG
    • $450.00
    • 100 MG
    • $750.00
    • 250 MG
    • $1300.00

Usually ships within 24 hours.


Would you like to inquire about custom quantity?
Inquire