DSPE-Polysarcosine150 is a a nonionic and hydrophilic polypeptoid conjugate based on the endogenous amino acid sarcosine (N-methylated glycine) with an average of 150 sarcosine units. 1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine (DSPE) is comprised of phosphorylethanolamine phospholipid acylated with fully saturated C18 fatty acids. Polysarcosine has been shown to have a higher protein secretion with a reduced immunostimulatory response observed when compared to systems based on polyethylene glycol (PEG) lipids. DSPE-Polysarcosine can be used in lipid formulas to create lipid nanoparticles (LNPs) for therapeutic applications of mRNA.
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