Azide-Polysarcosine20 is a lipid-polypeptoid conjugate based on the endogenous amino acid sarcosine (N-methylated glycine) with an average of 20 sarcosine units. The azide (N3) group is reactive with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. Polysarcosine has been shown to have a higher protein secretion with a reduced immunostimulatory response observed when compared to systems based on polyethylene glycol (PEG) lipids. Azide-Polysarcosine can be used to create lipids for the formation of lipid nanoparticles (LNPs) to be used in therapeutic application of messenger RNA.
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