1-[(5E)-3-O-[(Bis-diisopropylamino)(2-cyanoethoxy)phosphino]-5,6-dideoxy-6-(diethoxyphosphinyl)-2-O-(2-MOE)-β-D-ribo-hex-5-enofuranosyl]uracil

1-[(5E)-3-O-[(Bis-diisopropylamino)(2-cyanoethoxy)phosphino]-5,6-dideoxy-6-(diethoxyphosphinyl)-2-O-(2-MOE)-β-D-ribo-hex-5-enofuranosyl]uracil

1-[(5E)-3-O-[(Bis-diiPr-amino)(2-cyano ethoxy)phosphino]-5,6-dideoxy-6-(diethoxy phosphinyl)-2-O-(2-MeO-Et)-?-D-ribo-hex-5-enofuranosyl]uracil, containing a 2'-O-MOE-modified uridine nucleoside, can be used to form antisense RNA. The 2'-MOE backbone enhances duplex stability and nuclease protection.