mPEG4-Val-Ala-PAB-PNP is an ADC linker featuring a hydrophilic PEG spacer, a Val-Ala dipeptide, and a p-aminobenzyl (PAB) group a PAB group, and a PNP carbonate. The PNP carbonate is highly activated towards attack from amines to form carbamate structures with an amine group on a target molecule. The Val-Ala dipeptide is cleaved by proteases to release a given drug payload via an elimination mechanism within the PAB group.
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