N-(DBCO-PEG4-carbonyl)-N-bis(PEG4-acid) is a reagent combining two carboxylic acids and a DBCO moiety. The carboxylic acids can be reacted with primary amines in the presence of an activator such as HATU or EDC to form stable and water-soluble amide bonds, while the DBCO moiety is used in click chemistry with azides. The inclusion of a tertiary amide and PEG linkers improves this molecule’s aqueous solubility.
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