trans-Petroselinic acid is the trans isomer of petroselinic acid and an isomer of oleic acid that has been found in cow, goat, and ewe milk fat as well as human breast milk. In HepG2 cells, trans-petroselinic acid (100 μM) increases cellular content of triacylglycerols and cholesterol esters and upregulates transcription of genes involved in fatty acid synthesis, including SREBP-1c, ACACA, FASN, and SCD1, and cholesterol synthesis, including HMGCR, HMGCS1, FDFT1, and SREBP-2.
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