Azide-PEG4-Val-Cit-PABC-Exatecan is an enzymatically cleavable linker-payload conjugate, and it can be used in the synthesis of antibody-drug conjugates (ADCs). The Val-Cit will specifically be cleaved by Cathepsin B. Exatecan is a structural analog of camptothecin and shows anticancer activity. The azide group can react with alkyne, BCN, and DBCO via Click Chemistry.
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