MAL-PEG24-amido-PEG24-TFP ester functions as a long heterobifunctional PEG linker featuring a terminal thiol-reactive maleimide group and TFP ester, which can react with primary amine groups and is less susceptible to undergo hydrolysis compared to NHS ester. The PEG chain elevates the hydrophilicity of the compound and helps fine-tune DMPK properties.
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