Mal-PEG4-Val-Cit-PAB-MMAF functions as a linker-payload construct with a thiol-specific maleimide which is used to label cysteine residues in proteins and an enzymatically cleavable Val-Cit site. The Val-Cit will specifically be cleaved by Cathepsin B. MMAF is a synthetic antineoplastic agent that may be employed as a cytotoxic payload. Solubility in aqueous media is enhanced via the PEG chain.
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