Hoechst S769121 (Nuclear Yellow) is a cell-permeable yellow-emitting fluorescent dye that strongly attaches to adenine-thymine-rich regions within double-stranded DNA's minor groove. This dye finds application in fluorescence microscopy, fluorometry, and flow cytometry for staining and measuring DNA content in live and fixed cells. It is frequently paired with retrograde tracers like True Blue for dual-color neuronal imaging. Additionally, Nuclear Yellow can photoconvert diaminobenzidine (DAB) into an electron-dense reaction product, extending its utility to light and electron microscopy.
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