TMR-DN is a probe that combines 5-carboxy tetramethylrhodamine (TMR) with a quencher moiety, dinitroaniline (DN). It enables contact quenching, is non-toxic to cells, and can penetrate cell membranes. The core of the molecule contains an aromatic fragment with a negatively charged carboxylic group, providing bright fluorescence properties while minimizing nonspecific binding to genomic DNA or RNA.
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