β-NF-JQ1 is a PROTAC that employs Aryl Hydrocarbon Receptor (AhR) E3 ligase for targeted protein degradation. Utilizing β-NF as an AhR ligand, it specifically engages bromodomain-containing (BRD) proteins, promoting their interaction with AhR. This compound demonstrates significant efficacy in reducing BRD protein levels, which is associated with enhanced anticancer activity.
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