Tri-GalNAc-PEG4-DBCO is an azido-reactive asialoglycoprotein receptor (ASGPR) ligand which contains also three terminal beta-N-acetylgalactosamine (GalNAc) sugars for efficient ASGPR binding. The beta-alanine linker separates the GalNAc unit from a PEG4 spacer, improving water solubility and potentially influencing pharmacokinetics. The terminal DBCO group enables an effective conjugation to biomolecules containing azido groups via bioorthogonal CuAAC click chemistry. This strategy offers efficient and specific conjugation under mild conditions for researchers developing targeted therapeutics or probes. This multifunctional combination makes tri-GalNAc-PEG4-DBCO a versatile tool for researchers developing targeted therapies and diagnostics exploiting the ASGPR pathway.
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