Cytidine-diphosphate diacylglycerol (CDP-DG) is a precursor for the biosynthesis of many biological phospholipids including PI, PG, and PS. CDP-DG is produced in metabolic pathways through the reaction of cytidine 5’-triphosphate and PA which releases a phosphate group. Various glycerophosphate-based phospholipids are major components of biological membranes. These glycerophosphate-based phospholipids are found in many biological membranes as head-group modified phospholipids including PG, cardiolipin, PE, PS, and PA.
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