N-(Azido-PEG3)-N-(PEG4-Val-Cit-PAB-MMAE)-N-(PEG3-acid) represents a branched PEG linker that may be used in the construction of antibody-drug conjugates. The terminal azide can partake in click chemistry with BCN, DBCO, alkynes, and the terminal carboxylic acid can react with amine-bearing molecules in the presence of activators. The Val-Cit dipeptide is cleaved by cellular proteases like Cathepsin B within the cell to allow for efficient MMAE payload delivery via an elimination mechanism within the PAB structure. Water solubility of the molecule is enhanced via the PEG spacers. The branched architecture supports attachment of ADC payloads.
Usually ships within 24 hours.