Auristatin E is a cytotoxic tubulin modifier with potent and selective antitumor activity; it is a synthetic analog of dolastatin 10. Auristatin E is a highly potent antimitotic agent. Auristatin E inhibits tubulin polymerization(1). Auristatin E-antibody cunjugates have proven to be successful anticancer agents.(2)Ref. 1. Pettit et al. Anticancer Drug Des. 1995 10:529.Ref. 2. Doronina et al. Nature Biotechnol. 2003 21:778.
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