Methyltetrazine-PEG24-Acid is an aqueous soluble, monodisperse PEG reagent containing a click chemitstry group and terminal carboxylic acid. The acid (CO2H) can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. electron-donating properties of the methyl group enhances the stability of methyltetrazine-PEG4-Acid. Methyltetrazine enable fast click chemistry with TCO ((trans-cycloctene) under mild condition
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