7-Ethyl-10-hydroxycamptothecin

7-Ethyl-10-hydroxycamptothecin


7-Ethyl-10-hydroxycamptothecin (SN-38) is a topoisomerase I inhibitor, and it inhibits DNA and RNA synthesis with IC50s of 0.077 and 1.3 µM, respectively. SN-38 is the active component of ADC drugs, IMMU-132. and also is the active metabolite of irinotecan.

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