ADC Linkers

ADC Linkers

ADC linkers play key roles in determining the overall success of the Antibody drug conjugates. A well-designed linker can help the antibody to selectively deliver the cytotoxic drug to tumor cells and accurately release the cytotoxic drug at tumor sites. It also plays critical roles in an ADCs’ stability during preparation, storage, and systemic circulation. Two kinds of linkers are used in current ADC drugs: cleavable and non-cleavable.

BroadPharm offers a wide variety of ADC linkers such as Val-Cit, Val-Cit-PAB, Val-Cit-PAB-PNP, Gly-Gly, PEG Azide, Amino PEG, PEG Maleimide, DBCO, BCN, Tetrazine, TCO, and other linkers.

BroadPharm also offers customer-oriented ADC linker synthesis and services to our customers worldwide.