BCN reagents (bicyclo[6.1.0]nonyne) can react with azide-tagged molecules or biomolecules via copper-free Click Chemistry.
DBCO (Dibenzocyclooctyne) reagents is one of the most reactive cycloalkynes for strain promoted alkyne azide cycloaddition (SPAAC), which enables Cu-free Click Chemistry.
TCO reagents (Trans-Cyclooctene Reagents) can be used to label antibodies, proteins and other macromolecules via copper free Click Chemistry.
Tetrazine reagents can be applied for many applications such as antibody labeling and protein modification. Tetrazine was found the fastest kinetics for bioorthogonal reaction with trans-cyclooctene (TCO) as the dienophile. The chemical stability of tetrazines is lower compared to methyltetrazines.
Alkyne reagents can be reacted with azide-bearing compounds or biomolecules via Cu-catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage.
Azide Reagents enables Click Chemistry and can be used to react with amine-containing biomolecules, modifying carboxylic acid groups, and etc.