ADC linkers are the key components that connect an antibody and a pharmaceutically potent drug (payload) through a chemical bond. ADC linkers play key roles in determining the overall success of the Antibody Drug Conjugates (ADCs). A well-designed ADC linker can help the antibody to selectively deliver and accurately release the cytotoxic drug at tumor sites. It also plays critical roles in an ADCs' stability during preparation, storage, and systemic circulation. There are two kinds of ADC linkers in currently FDA approved ADC drugs: cleavable linkers and non-cleavable linkers.
BroadPharm provides a wide selection of ADC linker reagents such as Val-Cit, Val-Cit-PAB-PNP, Peptide PEG, PEG Azide, Thiol linker, Maleimide linker, Click Chemistry Linker, DBCO, BCN, TCO, Tetrazine and others.
BroadPharm also offers customer-oriented ADC linker synthesis and services to our customers