Click Chemistry is a chemical reaction between pairs of reagents (named click chemistry tools) to exclusively react with each other under mild condition and is effectively inert to naturally occurring functional groups such as the amine group. Click Chemistry has been widely used in bioconjugation, biolabeling and material sciences in pharmaceutical and biotech industry due to its mild conditions and high selectivity. Click Chemistry reactions can be categorized into three categories: (1) Cu(I)-catalyzed Azide-Alkyne Click Chemistry reaction (CuAAC); (2) Strain-promoted Azide-Alkyne Click Chemistry reaction (SPAAC). It is biocompatible. (3) Ligation between tetrazine and alkene (trans-Cyclooctene). This high-speed reaction is also copper free which is ideal for in vivo cell labeling. BroadPharm provides over 500 high purity Click Chemistry tools (reagents or kits) with a broad range of functional groups: Azide, Alkyne, DBCO, TCO, Tetrazine, BCN...
BCN reagent is a class of click chemistry reagents containing a very reactive BCN (bicyclo[6.1.0]nonyne) group, BCN reagents can react with azide-tagged molecules or biomolecules via copper-free Click Chemistry. It can be run either in aqueous buffer... Click to read more.
Alkyne reagents can be reacted with azide-bearing compounds or biomolecules via Cu-catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage.... Click to read more.
Azide click chemistry is a very popular chemistry that is widely used in pharmaceutical and biotech field due to its mild condition, fast speed and biocompatibility. The 1st generation of azide click chemistry is enabled through the reaction o... Click to read more.
DBCO reagent is a class of click chemistry labeling reagents containing a very reactive DBCO ((Dibenzocyclooctyne) group, DBCO reagent can react with azide-tagged molecules or biomolecules via copper-free Click Chemistry. The reaction can be run in a... Click to read more.
TCO click chemistry is the 3rd generation click chemistry that is widely used in labeling and bioconjugation due to its fast speed and biocompatibility. It is the reaction between TCO (trans-cycloctene) reagent and Tetrazine moiety in an inverse elec... Click to read more.
Tetrazine reagents is a class of click chemistry labeling reagents containing a reactive tetrazine group, Tetrazine reagent is highly reactive with TCO (trans-cycloctene) in an inverse electron demand Diels Alder reaction followed by a retro-Diels Al... Click to read more.
The efficiency of a copper (Cu(I))-catalyzed Azide-Alkyne click chemistry reaction (CuAAC) strongly depends on the presence of copper ions Cu(+I). Copper(I) ions are easily oxidized and undergo disproportionation, also has cytotoxic effects to liv... Click to read more.