PTAD Linker

PTAD Linker


PTAD linkers are bioconjugation linkers designed for selective modification of tyrosine residues in proteins and peptides. Featuring a PTAD (4-phenyl-3H-1,2,4-triazoline-3,5(4H)-dione) group, they react specifically with tyrosine while minimizing cross-reactivity with other amino acids. Often equipped with azide or alkyne groups, PTAD linkers enable bioorthogonal click chemistry, such as CuAAC, for attaching drugs, imaging agents, or probes. Variants with PEG spacers enhance solubility and flexibility, and some include cleavable motifs for controlled payload release in antibody-drug conjugates. PTAD-tyrosine bonds are stable across diverse pH and temperature conditions, making these linkers versatile for targeted drug delivery, protein labeling, and biosensor development.

Catalog Product Name Structure M.W. Purity Pricing
PTAD Amine
BP-24178PTAD-amineMolecular structure of the compound: PTAD-amine266.3Pricing
BP-43845PTAD-PEG4-amineMolecular structure of the compound: PTAD-PEG4-amine513.6Pricing
PTAD Azide
BP-43842PTAD-azideMolecular structure of the compound: PTAD-azide292.3Pricing
BP-25451PTAD-PEG4-AzideMolecular structure of the compound: PTAD-PEG4-Azide539.598%Pricing
PTAD Alkyne
BP-43843PTAD-alkyneMolecular structure of the compound: PTAD-alkyne261.2Pricing
BP-43844PTAD-PEG4-alkyneMolecular structure of the compound: PTAD-PEG4-alkyne508.5Pricing