PTAD-PEG4-amine is a heterobifunctional linker featuring a PTAD moiety for tyrosine-selective click reactions and a primary amine for further functionalization. PTAD enables highly chemoselective modification of tyrosine residues in peptides, proteins, and small molecules, outperforming maleimide linkages in stability under heat, extreme pH, and human plasma. The PEG4 spacer enhances solubility and improves bioconjugation efficiency. PTAD-PEG4-amine works across a broad pH range in biocompatible buffers without requiring metal catalysts.
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