PTAD-alkyne is a heterobifunctional linker combining a PTAD moiety for selective tyrosine click reactions with an alkyne handle for downstream click chemistry conjugation with azides. PTAD reagents are highly selective for tyrosine over cysteine and lysine, enabling precise modification of small molecules, peptides, and proteins in biologically compatible aqueous buffers across a broad pH range—without heavy metal catalysts. The resulting tyrosine click linkage is exceptionally stable, outperforming maleimides under heat, extreme pH, and in human plasma, making PTAD-alkyne ideal for robust, biocompatible bioconjugation.
Usually ships within 24 hours.