t-butyl-C18-D-Glu-OtBu-PEG2-amide-PEG2-amine is a PEG linker comprised of an octadecanedioic acid and a glutamic acid, which is also protected by a terminal t-butyl ester, with a terminal t-butyl ester and an amine. The t-butyl groups can be deprotected under acidic conditions. Glutamic acid is an α-amino acid that is used in the biosynthesis of proteins. The amine group is reactive with activated NHS esters, carbonyls (ketone, aldehyde), etc.
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