TCO-PEG12-amine is a PEG linker featuring a trans-cyclooctene and a primary amine. The amine is a versatile group which can react with carboxylic acids, NHS esters, or carbonyls while the TCO function is applied towards click chemistry with tetrazine-containing compounds. The half-life of TCO is short as it will naturally isomerize into CCO (cis-cycloctene) and lose the reactivity. TCO compound is not recommended for long term storage.
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