Methyltetrazine-PEG5-NH-Boc is a click chemistry crosslinker containing methyltetrazine and a Boc protecting group. Methyltetrazine enables fast click reaction with TCO (trans-cycloctene). The hydrophilic PEG spacer arm improves water solubility and is transferrable to the labeled molecule, reducing aggregation of labeled proteins stored in solution. The Boc protecting group can be removed under acidic conditions.
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